More than 2,000 tickets were sold to fill the hall at the Long Center. The night is being described as a conversation with Hillary Rodham Clinton.
"I learned two things. I learned a lot about losing," she told the crowd.
Before the keynote address, the former First Lady and U.S. Senator signed copies of her book entitled "Hard Choices."
One thousand people paid $35 a ticket to attend her book signing.
"I love you so much I've always wanted to meet her in person, it’s like my mom, first woman to be appointed to public office in my hometown, so they share that," said Armando Barron.
"Hard Choices" is a memoir about the crises, choices and challenges she faced during her four years as the Secretary of State.
Julie Johnson-Jones, said, "I'm ready for Hillary. We want to put another Clinton in office."
Political analysts see Clinton's stop in Austin as a second run for the White House, but not everyone welcomed her arrival.
A small group of protesters held signs in front of the Long Center.
Austin Police and the secret service worked together to coordinate the event.
"We need to learn to work together...compromise is not a dirty word," Clinton said.