Since the MS 150 began back in the mid '80s, the National MS Society says they've raised more than $185 million for Multiple Sclerosis research and awareness.
Anne Roland says she's living proof of what that fundraising can do.
"It's amazing what they're doing for people with MS. The money they're raising, I'm on this pill that helps me walk because of what they're doing. They've raised money and it's just...overwhelming," she said.
MS is a disease of the central nervous system that interrupts the flow of information between the brain and body.
Ride organizers say since there is no known cure, funding goes toward research, drug therapy and programs.
The 13,000 cyclists coming from Houston started the journey Saturday morning -- some riding as far as 180 miles depending on where they left from.
It's Leslie Smith's seventh year to ride.
"If you're gonna cycle, it's good to cycle for a cause you know, you get to give back doing something you love doing which is on the back of this bicycle," Smith said.
Hannah Milne is from Scotland but she lives outside of Houston now. Her husband and 2 kids drove in Sunday to pick her up after the long ride. She's glad she could help the cause.
"It's really incredible. And MS is a big thing in the UK as well so it's quite a privilege to ride and raise some money for a good cause," Milne said.
Milne says she's exhausted but some cyclists could have kept going.
"Went through the Bastrop park and that was a wonderful exhilarating ride. Like a roller coaster but a roller coaster on a bicycle so a total of 74 miles today and not tired, I'm all energized, I could have did another 25," Smith said.
The MS Society says the goal this year is to get to $18.5 million. They're well on their way. Fundraising ends this summer and they've already raised more than $14 million.