Officers and paramedics were called to Mesa High School on Wednesday afternoon on reports of 7 juvenile males who were experiencing a reaction after smoking an unknown substance.
About 2 p.m., 7 teenagers went to the nurse's office with rapid heartbeats, high blood pressure, and mild temperatures. They were all conscious, alert and breathing.
Four of the students were taken to the hospital for the elevated blood pressure, but were in stable condition.
The boys all denied smoking anything illegal, although one teen indicated they had smoked Spice.
However, police officers did not find any drugs in their possession.
Everyone involved was between the ages of 14 and 16.
Spice is a synthetic drug that can mimic the symptoms of marijuana, cocaine, or meth. Arizona has banned the sale of such compounds, but because chemists keep coming up with new variations, it's hard for the Legislature to keep up.